Spontaneous Miscarriages Are Explained by the Stress/Glucocorticoid/Lipoxin A4 Axis
نویسندگان
چکیده
منابع مشابه
Spontaneous miscarriages are explained by the stress/glucocorticoid/lipoxin A4 axis.
Despite various suspected causes, ranging from endocrine and genetic to infectious and immunological aspects, the molecular mechanisms of miscarriage still remain enigmatic. This work provides evidence that downregulation of 11β-hydroxysteroid dehydrogenase (HSD) type 2, the key enzyme inactivating glucocorticoid activities, insults the pregnant inflammatory milieu by inhibiting the biosynthesi...
متن کاملPolymorphisms in the ACE and PAI-1 genes are associated with recurrent spontaneous miscarriages.
BACKGROUND Successful pregnancies require fine tuning of fibrinolytic activities in order to secure fibrin polymerization and stabilization of the placental basal plate as well as to prevent excess fibrin deposition in placental vessels and intervillous spaces. Fibrinolysis is tightly regulated by plasminogen activator inhibitor-1 (PAI-1). Endothelial PAI-1 synthesis is induced by angiotensin I...
متن کاملValidation of second trimester miscarriages and spontaneous deliveries [Corrigendum]
[This corrects the article on p. 517 in vol. 7, PMID: 26715859.].
متن کاملValidation of second trimester miscarriages and spontaneous deliveries
OBJECTIVE To validate the diagnosis of second trimester miscarriages/deliveries (16+0 weeks to 27+6 weeks of gestation) recorded as miscarriages in the Danish National Patient Registry or spontaneous deliveries in the Danish Medical Birth Registry, and asses the validity of risk factors, pregnancy complications, and cerclage by review of medical records. MATERIALS AND METHODS In a cohort of 2...
متن کاملDouble trisomy in spontaneous miscarriages: cytogenetic and molecular approach.
BACKGROUND Although single trisomy is the most common chromosomal abnormality observed within first trimester spontaneous abortions (SA) (>50%), double trisomy (DT) ranges from 0.21 to 2.8% in the literature. Since little is known about mechanisms underlying DT, we report the results of our experience with 517 SA, establishing parental origin and cell stage of non-disjunction when possible in D...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2013
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.1202807